UCSF professor flags $1.34B Minnesota 340B windfall, as scrutiny grows over California’s use of the program

Anthony DiGiorgio, Assistant Professor of Neurological Surgery, UCSF
Anthony DiGiorgio, Assistant Professor of Neurological Surgery, UCSF
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Anthony DiGiorgio, Assistant Professor at the University of California, San Francisco (UCSF), said on X that Minnesota’s new 340B report shows the program is generating billion-dollar net revenue for hospitals and fueling consolidation rather than targeting safety-net care, as similar concerns grow in California.

The topic has drawn attention as policymakers and health professionals debate whether the federal 340B Drug Pricing Program is fulfilling its intended purpose. DiGiorgio said, “$1.34 BILLION in net 340B revenue in a single year. That’s a massive, unregulated corporate windfall. These subsidies are unavailable to independent physicians.”

DiGiorgio added, “And no, this isn’t ‘for the safety net.’ ~81% of MN’s 340B net revenue was captured by just 23 DSH hospitals. Safety net clinics got under 1% of net 340B revenue statewide. So spare me the press releases about the underserved. They are the marketing face for a program that mostly bankrolls big hospital expansion. Judge a policy not by its intent but by its outcomes outcome is clear: it’s a disaster. The MN report proves 340B is no longer a small program for clinics; it’s a billion-dollar subsidy for hospital consolidation.”

The Star Tribune reported that Minnesota’s 340B net revenue is highly concentrated among the biggest hospital participants. M Health Fairview’s University of Minnesota Medical Center generated about $334.7 million in net 340B revenue in 2024, roughly one quarter of the statewide total by itself, while the largest hospitals collectively captured around 80% of Minnesota’s net 340B revenue, dwarfing smaller providers in the program.

In California, 79% of 340B hospitals report below-average charity care, a key reason skeptics say the program can miss patients it was designed to help. When discounted drugs are billed at standard rates, hospitals may keep the spread while patients, especially those uninsured or with high cost-sharing, see little direct relief in out-of-pocket costs.

Created by Congress in 1992, the federal program requires Medicaid-participating manufacturers to sell outpatient drugs at discounted prices to eligible covered entities, with oversight from the Health Resources and Services Administration (HRSA). Recent Government Accountability Office reviews warn of persistent vulnerabilities such as duplicate discounts and gaps around contract pharmacies and recommend further actions to strengthen oversight.

DiGiorgio’s background includes clinical and research interests spanning traumatic brain injury and health policy, according to UCSF Profiles. He continues to comment publicly on issues related to healthcare programs like 340B.



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